February
Check out our latest publication showing the first flow synthesis of modafinil. This work was performed by Dr. Diana Silva at the Center for Integrated Technology and Organic Synthesis (CITOS)under the mentorship of our collaborator Dr. Monbalilu from the University of Liege, Belgium. This NASA sponsored research is aimed at developing an end-to-end process for the synthesis, purification, and formulation of Modafinil. Congratulations to all authors!
DOI: doi.org/10.1039/D1GC04666G |
March
We are excited to announce our latest publication: “High-affinity zoledronate-based metal complex nanocrystals to potentially treat osteolytic metastases” in Materials Advances from the Royal Society of Chemistry. In this publication, our CDI graduate students Gabriel Quiñones, Lesly Carmona, and our former undergraduate Alondra Rivera, in collaboration with Dr. Esther Peterson from the Biology Department at UPR-Rio Piedras and Dr. Hu from New York University, explored the design of several materials known as zoledronate-based coordination complexes, as well as their synthesis at the nanometer-range. Several biomedical properties of the resulting nanocrystals were demonstrated, such as a pH-dependent degradation, low aggregation in physiological media, high binding affinity to the bone, and significant cytotoxicity against a metastatic breast cancer cell model. These promising outcomes suggest the potential of the nanocrystals for osteolytic metastases therapy. Additionally, the present work under the leadership of Dr. Vilmalí López-Mejías from the CDI led to the submission and approval of a provisional patent “Zoledronate Coordination Nanocrystals for Cancer and Bone Therapy” submitted by the Puerto Rico Science, Technology and Research Trust. Congratulations to all authors and inventors. #TeamCDI
The following link provides free access to the article as the journal is open access: https://pubs.rsc.org/.../articlepdf/2022/ma/d1ma01127h |
April
We are excited to announce our latest publication: “Polymorphic Phase Transformations in Crystalline Solid Dispersions: The Combined Effect of Pressure and Temperature” in Crystal Growth & Design from the American Chemical Society. In this publication, our CDI graduate students Francheska Reyes Figueroa, José Hernández Espinell, and our former undergraduate student Marileyda Hernández Hernández explored the effect of temperature and pressure typically encountered in Hot Melt Extrusion and 3D Printing technologies on inducing polymorphic phase transformations. The results contribute to the understanding of extrusion processes that can enable advanced polymer-based formulations containing metastable polymorphs.
The following link provides access to the article: https://pubs.acs.org/doi/10.1021/acs.cgd.1c01289 |
May
Check out our latest publication on polymorphic selectivity in crystal nucleation at The Journal of Chemical Physics (https://doi.org/10.1063/5.0086308). This work was performed by the graduate student, Yue Gui (University of Wisconsin-Madison) from our collaborators Lian Yu at University of Wisconsin-Madison and Dr. Geoff Zhang (Abbvie) as part of our fruitful collaboration within the Wisconsin-Puerto Rico Partnership for Research and Education in Materials (WiPREM). In this work, the crystal nucleation rates in the melts of two richly polymorphic substances: 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (ROY) and nifedipine (NIF) was measured. Congratulations to all authors!
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We at the Crystallization Design Institute are excited to announce our latest publication: “Solvent-Mediated Polymorphic Transformations in Molten Polymers: The Account of Acetaminophen” in the journal Molecular Pharmaceutics from the American Chemical Society. This work was performed by our graduate student José R. Hernández Espinell and undergraduate student Verónica Toro in collaboration with the graduate student Xin Yao and his mentor Dr. Lian Yu from the University of Wisconsin-Madison as part of the National Science Foundation funded project “(WIPREM)”. In this work, the solvent-mediated polymorphic transformation induction time is determined in polymer melts, which allows to understand the kinetically controlled access of metastable forms and how to delay their transformation.
The following link provides access to the article: https://doi.org/10.1021/acs.molpharmaceut.2c00035 |
We at the #Crystallization Design Institute are excited to announce our latest collaborative publication entitled “Surfactants Accelerate Crystallization of Amorphous Nifedipine by Similar Enhancement of Nucleation and Growth Independent of Hydrophilic–Lipophilic Balance” in the journal Molecular Pharmaceutics from the American Chemical Society. This work was performed by the graduate students Xin Yao, Emily Benson, and Yue Gui under the leadership of Dr. Lian Yu from University of Wisconsin-Madison and Dr. Geoff Zhang from Abbvie in collaboration with Dr. Torsten Stelzer from the #TeamCDI.
The following link provides access to the article: https://doi.org/10.1021/acs.molpharmaceut.2c00156 |
We are excited to announce the latest book chapter of the #CrystallizationDesignInstitute entitled “Recent Advances for Solid–Liquid Separation by Crystallization”. It was published in the book “Solid-Liquid Separation Technologies – Applications for Produced Water” edited by Dr. Olayinka I. Ogunsola and Dr. Isaac K. Gamwo. The book chapter is the result of the collaboration of Dr. Torsten Stelzer with Prof. Alison Lewis from the Department of Chemical Engineering and director of the Crystallization and Precipitation Research Unit (http://www.crystal.uct.ac.za) at the University of Cape Town, South Africa.
The following link provides access to the book: https://doi.org/10.1201/9781003091011 |
December
The #CrystallizationDesignInstitute is excited to announce our latest publication: “Role of Heteronucleants in Melt Crystallization of Crystalline Solid Dispersions” in the journal Crystal Growth & Design from the American Chemical Society (https://doi.org/10.1021/acs.cgd.2c00444). This work was performed by our graduate student Giovanni López Burgos and former graduate student Dr. José R. Hernández Espinell and undergraduate student Tatiana Graciani-Massa in collaboration with the graduate students Xin Yao and Kennedy Borchardt-Setter, and their mentor Dr. Lian Yu from the University of Wisconsin-Madison as part of the National Science Foundation funded project “WIPREM”. Congratulations to all authors! #TeamCDI
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More exciting news from the #CrystallizationDesignInstitute, as we announce our latest publication: “Polymorphic Control in Titanium Dioxide Particles” in the journal Nanoscale Advances from the Royal Society of Chemistry. This work was performed by our former graduate student Dr. Gabriel Quiñones Vélez, and former undergraduate students Diego Soto Nieves and Anushka Castro Vazquez under the leadership of Dr. Vilmalí Lopez-Mejías. Here, the reaction for the formation of TiO2 was adapted to the phase inversion temperature (PIT)-nano-emulsion method, leading to the selective formation of highly pure rutile, anatase, and brookite particles of this metal oxide. This work was fully supported by the National Science Foundation PREM-Center for Interfacial Electrochemistry of Energy Materials (CiE2M). Congratulations to all authors! #TeamCDI
The following link provides free access to the article as the journal is open access: https://doi.org/10.1039/D2NA00390B |